Unrelated bone marrow transplantation for leukocyte adhesion deficiency
نویسندگان
چکیده
منابع مشابه
Results of allogeneic bone marrow transplantation in patients with leukocyte adhesion deficiency.
We have retrospectively analyzed the outcome of bone marrow transplantation (BMT) in 14 patients with leukocyte adhesion deficiency (LAD) performed in two centers between 1981 and 1993. Five patients received BMT from HLA-identical donors. Nine received T-depleted marrow from two HLA antigen- or haplotype-incompatible parents. Conditioning regimen consisted of chemotherapy exclusively in 13 pat...
متن کاملSuccessful HLA nonidentical bone marrow transplantation in three patients with the leukocyte adhesion deficiency.
Three consecutive patients with the severe phenotype of leukocyte adhesion deficiency characterized by a defective expression of LFA-1, Mac-1 (CR3), and p150.95 on leukocytes have received HLA partially incompatible bone marrow transplantation (BMT). The degree of HLA incompatibility between related donors and recipients was 2 HLA antigens in one and one full haplotype in the two others. Graft-...
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The efficacy and toxicity of donor leukocyte infusions (DLI) after unrelated donor bone marrow transplantation (BMT) is largely unknown. We identified 58 recipients of unrelated DLI (UDLI) for the treatment of relapsed disease from the National Marrow Donor Program database. A retrospective analysis was performed to determine response, toxicity, and survival after UDLI and to identify factors a...
متن کاملLeukocyte Adhesion Deficiency Type 1 Presenting as Leukemoid Reaction
The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...
متن کاملImmune-mediated optic neuritis after unrelated allogeneic bone marrow transplantation.
There have been few reports on immune-mediated neurological disturbances and none on solitary occurrence of optic neuritis after bone marrow transplantation (BMT). We experienced a very rare case of immune-mediated optic neuritis as one symptom of graft-versus-host disease (GVHD). A 34-year-old man with chronic myelogenous leukemia in accelerated phase received BMT from a human leukocyte antige...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2002
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1703719